Several years ago, we set out to write a short biochemistry textbook that combined succinct, clear chapters with extensive problem sets. We believed that students would benefi t from a modern approach involving broad but not overwhelming coverage of biochemical facts, focusing on the chemistry behind biology, and providing students with practical knowledge and problem-solving opportunities. Our experience in the classroom continues to remind us that eff ective learning also requires students to become as fully engaged with the material as possible. To that end, we have embraced a strategy of posing questions and suggesting study activities throughout each chapter, so that students will not simply read and memorize but will explore and discover on their own—a truer refl ection of how biochemists approach their work in the laboratory or clinic.
As always, we view our textbook as a guidebook for students, providing a solid foundation in biochemistry, presenting complete, up-to-date information, and showing the practical aspects of biochemistry as it applies to human health, nutrition, and disease. We hope that students will develop a sense of familiarity and comfort as they encounter new material, explore it, and test their understanding through problem solving.
New to This Edition
Many details in the text and illustration program have been updated, with virtually no section left untouched. Some signifi cant changes are worth mentioning: Chapter 3 includes an updated discussion of genomics and a completely new presentation of DNA sequencing technologies and the use of CRISPR-Cas to edit genes. Other new items include a discussion of archaeal lipids, details on the GLUT membrane transport protein, a box on exosomes, new illustrations of respiratory cilia and bacterial peptidoglycan, new molecular graphics of mitochondrial respiratory complexes, an updated presentation of the ribonucleotide reductase mechanism, and more information on the microbiome, cancer, and obesity. Descriptions of DNA replication and transcription have been extensively modifi ed, with numerous new diagrams to present a more realistic picture of these processes. The histone code and readers, writers, and erasers are explained. New details on RNA splicing and protein translocation round out the revised text.
Eight health-related topics that were previously confi ned to short boxes have been updated and expanded to Clinical Connection sections to give them the appropriate attention: 2.5 Acid–Base Balance in Humans, 4.5 Protein Misfolding and Disease, 5.2 Hemoglobin Variants, 6.5 Blood Coagulation, 7.4 Drug Development, 13.5 Disorders of Carbohydrate Metabolism, 19.4 Cancer Metabolism, and 20.4 Cancer as a Genetic Disease.
With the same goal of making it easy for students to navigate complex topics, some material within sections has been reorganized, and several new sections of text now focus on key content areas: 14.3 Thermodynamics of the Citric Acid Cycle, 17.1 Lipid Transport, 18.5 Nucleotide Metabolism, 20.5 DNA Packaging, 21.1 Initiating Transcription, and 22.1 tRNA and the Genetic Code.
Above all, the focus of the fourth edition is ease of use, particularly for students and instructors taking advantage of new ways to assess student understanding. New Learning Objectives at the start of every section are based on verbs, giving students an indication of what they need to be able to do, not just know. Before You Go On study hints at end of each section reinforce the activities that support learning. The endof- chapter problem sets have been refreshed, with a total of 1,624 problems (averaging 74 per chapter, an increase of 18% over the previous edition). Problems are grouped by section and off ered in pairs, with the answers to odd-numbered problems provided in an appendix.
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|September 6, 2017|
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